Print Media vs. Digital Manifest Destiny

Every communications medium reflects and reinforces intellectual habits and content patterns unique to the medium. A digital/internet hegemony is a paradoxical foreclosure on breadth of mind since digital formats do not reflect or reinforce the intellectual habits and content patterns unique to other media, especially books. A credible educational process w ill take appropriate advantage of digital media without allowing its influence to repress breadth of mind

Corrigendum: Community-based screening and testing for Coronavirus in Cape Town, South Africa: Short report

David N, Mash R. Corrigendum: Community-based screening and testing for Coronavirus in Cape Town, South Africa: Short report. Afr J Prm Health Care Fam Med. 2021;13(1), 2832. https://doi.org/10.4102/phcfm.v13i1.2832The original publication available at http://www.phcfm.orgIn the version of the article initially published, David N, Mash R. Community-based screening and testing for Coronavirus in Cape Town, South Africa: Short report. Afr J Prm Health Care Fam Med. 2020;12(1), a2499. https://doi.org/10.4102/phcfm.v12i1.2499, one affiliation for the first author, Neal David, was omitted in the ‘Authors’ and ‘Affiliations’ sections. The following affiliation should be added as his second affiliation: Division of Family Medicine, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. This correction does not alter the study’s findings of significance or overall interpretation of the study’s results. The authors apologise for any inconvenience caused

The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human

Abstract Background As a model organism in biomedicine, the rhesus macaque (Macaca mulatta) is the most widely used nonhuman primate. Although a draft genome sequence was completed in 2007, there has been no systematic genome-wide comparison of genetic variation of this species to humans. Comparative analysis of functional and nonfunctional diversity in this highly abundant and adaptable non-human primate could inform its use as a model for human biology, and could reveal how variation in population history and size alters patterns and levels of sequence variation in primates. Results We sequenced the mRNA transcriptome and H3K4me3-marked DNA regions in hippocampus from 14 humans and 14 rhesus macaques. Using equivalent methodology and sampling spaces, we identified 462,802 macaque SNPs, most of which were novel and disproportionately located in the functionally important genomic regions we had targeted in the sequencing. At least one SNP was identified in each of 16,797 annotated macaque genes. Accuracy of macaque SNP identification was conservatively estimated to be >90%. Comparative analyses using SNPs equivalently identified in the two species revealed that rhesus macaque has approximately three times higher SNP density and average nucleotide diversity as compared to the human. Based on this level of diversity, the effective population size of the rhesus macaque is approximately 80,000 which contrasts with an effective population size of less than 10,000 for humans. Across five categories of genomic regions, intergenic regions had the highest SNP density and average nucleotide diversity and CDS (coding sequences) the lowest, in both humans and macaques. Although there are more coding SNPs (cSNPs) per individual in macaques than in humans, the ratio of dN/dS is significantly lower in the macaque. Furthermore, the number of damaging nonsynonymous cSNPs (have damaging effects on protein functions from PolyPhen-2 prediction) in the macaque is more closely equivalent to that of the human. Conclusions This large panel of newly identified macaque SNPs enriched for functionally significant regions considerably expands our knowledge of genetic variation in the rhesus macaque. Comparative analysis reveals that this widespread, highly adaptable species is approximately three times as diverse as the human but more closely equivalent in damaging variation.http://deepblue.lib.umich.edu/bitstream/2027.42/112453/1/12863_2011_Article_1004.pd

COP27 Climate Change Conference: Urgent action needed for Africa and the world

Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate change.The 2022 report of the Intergovernmental Panel on Climate Change (IPCC) paints a dark picture of the future of life on earth, characterised by ecosystem collapse, species extinction, and climate hazards such as heatwaves and floods. These are all linked to physical and mental health problems, with direct and indirect consequences of increased morbidity and mortality. To avoid these catastrophic health effects across all regions of the globe, there is broad agreement—as 231 health journals argued together in 2021—that the rise in global temperature must be limited to less than 1.5oC compared with pre-industrial levels. While the Paris Agreement of 2015 outlines a global action framework that incorporates providing climate finance to developing countries, this support has yet to materialise. COP27 is the fifth Conference of the Parties (COP) to be organised in Africa since its inception in 1995. Ahead of this meeting, we—as health journal editors from across the continent—call for urgent action to ensure it is the COP that finally delivers climate justice for Africa and vulnerable countries. This is essential not just for the health of those countries, but for the health of the whole world

COP27 CLIMATE CHANGE CONFERENCE: URGENT ACTION NEEDED FOR AFRICA AND THE WORLD

Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate chang

COP27 climate change conference: Urgent action needed for Africa and the world

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COP27 Climate Change Conference: urgent action needed for Africa and the world

No abstract

COP27 Climate Change Conference: urgent action needed for Africa and the world

No abstract